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Int J Circumpolar Health. 2005 Sep;64(4):387-95.

Eskimos have CHD despite high consumption of omega-3 fatty acids: the Alaska Siberia project.

Author information

1
Department of Neurological Surgery, University of Virginia, Charlottesville 22908-0212, USA. se6b@virginia.edu

Abstract

OBJECTIVES:

The thirty-year-old hypothesis that omega-3 fatty acid (FA) may "reduce the development of thrombosis and atherosclerosis in the Western World" still needs to be tested. Dyerberg-Bang based their supposition on casual observations that coronary atherosclerosis in Greenlandic Inuit was 'almost unknown' and that they consumed large amounts of omega-3 FAs. However, no association was demonstrated with data.

STUDY DESIGN:

Cross-sectional study.

METHODS:

454 Alaskan Eskimos were screened for coronary heart disease (CHD), using a protocol that included ECG, medical history, Rose questionnaire, blood chemistries, including plasma FA concentrations, and a 24-hour recall and a food frequency questionnaire assessment of omega-3 FA consumption.

RESULTS:

CHD was found in 6% of the cohort under 55 years of age and in 26% of those > or = 55 years of age. Eskimos with CHD consume as much omega-3 FAs as those without CHD, and the plasma concentrations confirm that dietary assessment.

CONCLUSIONS:

Average daily consumption of omega-3 FAs among Eskimos was high, with about 3-4 g/d reported, compared with 1-2 g/d used in intervention studies and the average consumption of 0.2 g/d by the American population. There was no association between current omega-3 FA consumption/blood concentrations and the presence of CHD.

PMID:
16277122
DOI:
10.3402/ijch.v64i4.18015
[Indexed for MEDLINE]

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