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Bioorg Med Chem Lett. 2006 Jan 15;16(2):373-7. Epub 2005 Nov 3.

Potent anti-muscarinic activity in a novel series of quinuclidine derivatives.

Author information

1
UCB Pharma, Chemin du Foriest, 1420 Braine l'Alleud, Belgium.

Abstract

The synthesis and biological evaluation of a novel family of M(3) muscarinic antagonists are described. A systematic modification of the substituents to a novel alkyne-quinuclidine scaffold yielded original compounds displaying potent in vitro anticholinergic properties.

PMID:
16275087
DOI:
10.1016/j.bmcl.2005.09.079
[Indexed for MEDLINE]

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