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Bioorg Med Chem Lett. 2006 Jan 15;16(2):307-10. Epub 2005 Nov 3.

A new chemical tool for exploring the physiological function of the PDE2 isozyme.

Author information

1
Research Technology Center, Pfizer, Inc., 620 Memorial Drive, Cambridge, MA 02139, USA. Robert.J.Chambers@pfizer.com

Abstract

Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2.

PMID:
16275071
DOI:
10.1016/j.bmcl.2005.10.005
[Indexed for MEDLINE]

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