Abstract
FGF signaling has been implicated as an important regulator of retinal development. As a first step in characterizing potential downstream targets of FGF signaling in the retina, we have analyzed expression of Pea3, a member of the Pea3 class of Ets-domain transcription factors, in the developing eye. We find that Pea3 is expressed in the developing retina, and its transcription is regulated by FGF receptor activation. In addition, FGF signaling activates Cath5, a gene necessary for retinal ganglion cell differentiation. These results suggest that FGF signaling via MAPK up-regulates transcription factors that in turn control retinal ganglion cell differentiation.
Copyright 2005 Wiley-Liss, Inc.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Basic Helix-Loop-Helix Transcription Factors / genetics
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Cell Differentiation
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Chick Embryo
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Fibroblast Growth Factors / metabolism*
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Flavonoids / pharmacology
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Gene Expression Regulation, Developmental / drug effects
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Gene Expression Regulation, Developmental / genetics*
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Protein Kinase Inhibitors / pharmacology
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RNA, Messenger / genetics
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Retina / cytology
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Retina / drug effects
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Retina / embryology*
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Retina / metabolism*
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Retinal Ganglion Cells / cytology
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Retinal Ganglion Cells / metabolism
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Signal Transduction*
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Transcription Factors / genetics
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Transcription Factors / metabolism*
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Up-Regulation / drug effects
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Up-Regulation / genetics
Substances
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Basic Helix-Loop-Helix Transcription Factors
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Flavonoids
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Protein Kinase Inhibitors
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RNA, Messenger
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Transcription Factors
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transcription factor PEA3
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Fibroblast Growth Factors
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2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one