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Nat Med. 2005 Dec;11(12):1293-4. Epub 2005 Nov 6.

Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor.

Author information

1
Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, Louisiana 70433, USA.

Abstract

Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10-14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.

PMID:
16273102
DOI:
10.1038/nm1321
[Indexed for MEDLINE]

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