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Postgrad Med J. 2005 Nov;81(961):719-22.

Pragmatic, observational study of bupropion treatment for smoking cessation in general practice.

Author information

1
Centre for Primary and Community Care, School of Health Natural and Social Sciences, University of Sunderland, UK. scott.wilkes@sunderland.ac.uk

Abstract

BACKGROUND:

Cigarette smoking remains the single largest cause of premature death in the United Kingdom. As part of the government's national service framework for coronary heart disease, smoking cessation forms a key part of the strategy.

OBJECTIVES:

To determine the effectiveness of bupropion treatment for smoking cessation in a general practice setting, measuring continuous abstinence from smoking, from 8 weeks to 52 weeks.

DESIGN:

Prospective observational study.

SETTING:

One general practice (six whole time equivalent doctors, 11,070 patients) in rural Northumberland.

SUBJECTS:

Of the 243 patients who presented to the practice over a one year period for smoking cessation, a total of 227 motivated people, who were appropriate for bupropion treatment as a pharmacological aid for smoking cessation, entered the study. Continuous smoking cessation at one year was validated by an exhaled carbon monoxide level of 10 ppm or less.

RESULTS:

Fifty patients successfully gave up smoking, giving a one year smoking cessation prevalence with bupropion of 22% (95% confidence intervals (CI) 17% to 28%). There was no difference in success rate for sex, number of cigarettes smoked, the number of years smoking, or whether there were other smokers in the household or not.

CONCLUSION:

Bupropion treatment in this general practice helped 22% of motivated people to quit and remain stopped smoking at one year. Mainly nurses, whose prescribing rights are restricted and currently exclude bupropion, deliver smoking cessation services in primary care.

PMID:
16272237
PMCID:
PMC1743391
DOI:
10.1136/pgmj.2005.032433
[Indexed for MEDLINE]
Free PMC Article
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