Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2006 Feb;16(3):658-62. Epub 2005 Nov 2.

Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: Quinolin(di)one and benzazepin(di)one derivatives. herve.geneste@abbott.com.

Author information

1
Abbott GmbH & Co. KG, Discovery Research, D-67008 Ludwigshafen, Germany.

Abstract

The synthesis and SAR of novel and selective dopamine D(3)-receptor antagonists based on a 3,4-dihydro-1H-quinolin-2-one, a 1,3,4,5-tetrahydro-benzo[b]azepin-2-one, 1H-quinoline-2,4-dione or a 3,4-dihydro-1H-benzo[b]azepine-2,5-dione scaffold are discussed. A706149 (2.15mg/kg, po) antagonizes PD 128907-induced huddling deficits in rat, a social interaction paradigm.

PMID:
16271293
DOI:
10.1016/j.bmcl.2005.10.035
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center