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World J Gastroenterol. 2005 Oct 7;11(37):5757-62.

Polymorphism of CYPIA1 and GSTM1 genes associated with susceptibility of gastric cancer in Shandong Province of China.

Author information

1
Center of Tumour Treatment, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China. haoli611@yahoo.com

Abstract

AIM:

To explore whether polymorphisms of the CYPIA1 and GSTM1 genes are associated with susceptibility of stomach cancer.

METHODS:

A total of 102 stomach cancer cases and 62 healthy persons were diagnosed by pathology in 1998-2000 in the Qilu Hospital of Shandong University. Gene polymorphisms were detected by the PCR using sequence-specific primers. Data analysis of the case-control study was carried out using the unconditional logistic method.

RESULTS:

After adjustment for age, sex, educational levels, and occupation, the risk factors for stomach cancer were shown to be smoking, Helicobacter pylori (H pylori), and presence of the CYPIM G/G and GSTM1 O/O genotypes. Interaction was observed between the combined genotypes of either CYPIA1 G/G and GSTM1 O/O or H pylori infection, or GSTM1 O/O and H pylori infection or smoking.

CONCLUSION:

Polymorphisms of the CYPIA1 and GSTM1 genes, H pylori infection and smoking are related to susceptibility to stomach cancer.

PMID:
16270381
PMCID:
PMC4479672
DOI:
10.3748/wjg.v11.i37.5757
[Indexed for MEDLINE]
Free PMC Article

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