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Appl Environ Microbiol. 2005 Nov;71(11):6934-46.

Identifying components of the NF-kappaB pathway in the beneficial Euprymna scolopes-Vibrio fischeri light organ symbiosis.

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1
Department of Medical Microbiology and Immunology, University of Wisconsin, 1300 University Ave., Madison, WI 53706, USA.

Abstract

The Toll/NF-kappaB pathway is a common, evolutionarily conserved innate immune pathway that modulates the responses of animal cells to microbe-associated molecular patterns (MAMPs). Because MAMPs have been implicated as critical elements in the signaling of symbiont-induced development, an expressed sequence tag library from the juvenile light organ of Euprymna scolopes was used to identify members of the Toll/NF-kappaB pathway. Full-length transcripts were identified by using 5' and 3' RACE PCR. Seven transcripts critical for MAMP-induced triggering of the Toll/NF-kappaB phosphorylation cascade have been identified, including receptors, signal transducers, and a transcription factor. Further investigations should elucidate the role of the Toll/NF-kappaB pathway in the initiation of the beneficial symbiosis between E. scolopes and Vibrio fischeri.

PMID:
16269728
PMCID:
PMC1287678
DOI:
10.1128/AEM.71.11.6934-6946.2005
[Indexed for MEDLINE]
Free PMC Article
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