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Cell. 2005 Nov 4;123(3):375-82.

Membrane hemifusion: crossing a chasm in two leaps.

Author information

1
Section on Membrane Biology, Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. chernoml@mail.nih.gov

Abstract

During membrane fusion, the outer leaflets of the two membranes merge first, whereas the distal membrane leaflets remain separate until the opening of a fusion pore. This intermediate stage, called hemifusion, is a critical event shared by exocytosis, protein trafficking, and viral entry.

PMID:
16269330
DOI:
10.1016/j.cell.2005.10.015
[Indexed for MEDLINE]
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