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Cell. 2005 Nov 4;123(3):361-3.

The proteasome: not just degrading anymore.

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1
Department of Biochemistry and Molecular Genetics, University of Virginia Schol of Medicine, Charlottesville, Virginia 22908, USA.

Abstract

The proteasome is a large multiprotein complex that has a critical role in the degradation of ubiquitylated proteins. A fascinating paper in this issue of Cell (Lee et al., 2005) now reveals that the proteasome recruits the SAGA histone acetyltransferase complex to a target promoter during gene activation. This finding adds to the growing body of evidence indicating that the proteasome has nonproteolytic functions.

PMID:
16269325
DOI:
10.1016/j.cell.2005.10.013
[Indexed for MEDLINE]
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