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Org Lett. 2005 Nov 10;7(23):5261-4.

Antineoplastic diterpene-benzoate macrolides from the Fijian red alga Callophycus serratus.

Author information

1
School of Biology and School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA. julia.kubanek@biology.gatech.edu

Abstract

[structures: see text] Three diterpene-benzoate natural products, with novel carbon skeletons and an unusual proposed biosynthesis, were isolated from extracts of the Fijian red alga Callophycus serratus and identified by a combination of X-ray crystallographic, NMR, and mass spectral analyses. Bromophycolide A (1) displayed cytotoxicity against several human tumor cell lines via specific apoptotic cell death. This represents the first discovery of natural products incorporating a diterpene and benzoate skeleton into a macrolide system.

PMID:
16268553
PMCID:
PMC3374863
DOI:
10.1021/ol052121f
[Indexed for MEDLINE]
Free PMC Article

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