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Org Lett. 2005 Nov 10;7(23):5237-9.

Mild and reversible dehydration of primary amides with PdCl2 in aqueous acetonitrile.

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1
Vicuron Pharmaceuticals, via R. Lepetit 34, Gerenzano (VA), Italy. smaffioli@vicuron.it

Abstract

[reaction: see text] A new, mild, and reversible method to convert primary amides to nitriles in good yields using PdCl2 in aqueous acetonitrile is described.

PMID:
16268547
DOI:
10.1021/ol052100l
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