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Respir Med. 2006 Jun;100(6):1105-9. Epub 2005 Nov 2.

Cough frequency, cough sensitivity and health status in patients with chronic cough.

Author information

1
Department of Respiratory Medicine, Institute for Lung Health, Glenfield Hospital, Leicester, LE3 9QP, UK. sb134@le.ac.uk

Abstract

BACKGROUND:

Little is known about the frequency of cough in health and in patients with chronic cough.

METHODS:

We measured cough frequency and its relationship with other markers of cough severity in 20 patients with chronic cough and 9 healthy subjects using the Leicester Cough Monitor (LCM), which is an automated ambulatory digital cough monitor that records sound only. All subjects had a 6-h recording and recordings were manually counted. A subgroup of 6 normals and 6 patients with a stable chronic cough had repeat measurements up to 6 months apart.

RESULTS:

Mean (sem) cough counts/hour were 43(8) in patients with chronic cough and 2(1) in normals (mean difference 41; 95% confidence interval 24-59; P<0.001). The cough counts were repeatable (within subject standard deviation: 23 coughs/hour; intraclass correlation coefficient 0.8). Cough counts correlated significantly with physical (r=-0.6, P=0.03), social (r=-0.7, P=0.01) and total Leicester Cough Questionnaire (LCQ) health status scores (r=-0.6, P=0.03) and cough sensitivity (concentration of capsaicin causing 5 coughs: r=0.9, P=0.008).

CONCLUSION:

We have shown that there are marked differences in cough frequency between patients with chronic cough and healthy subjects, that these measurements are repeatable, and that they correlate with cough-specific health status.

PMID:
16266801
DOI:
10.1016/j.rmed.2005.09.023
[Indexed for MEDLINE]
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