The significance of carboxy-terminal telopeptide of type I collagen (ICTP) and osteocalcin (OC) in assessment of bone disease in patients with multiple myeloma

Leuk Lymphoma. 2005 Dec;46(12):1749-53. doi: 10.1080/10428190500232428.

Abstract

Bone disease occurring in multiple myeloma is usually evaluated using radiological methods. These methods, however, provide not much information about the dynamic process of bone resorption and formation. This study analysed levels of serum markers of bone turnover (ICTP and OC), reflecting function of osteoclasts and osteoblasts. It demonstrates increased level of ICTP in 75 patients with MM compared to control group (8 persons) and patients with Waldenström's macroglobulinemia (10 persons). The level of ICTP was also higher in patients with more advanced bone disease and probably in higher stage of disease according to Salmon and Durie classification. This tendency was not observed in relation to OC. Result of the research confirms that ICTP may incur sensitive and specific markers of bone lesions in multiple myeloma.

MeSH terms

  • Absorptiometry, Photon
  • Biomarkers / blood
  • Bone Diseases / blood
  • Bone Diseases / diagnosis*
  • Bone Diseases / etiology
  • Collagen / blood*
  • Collagen Type I
  • Female
  • Humans
  • Male
  • Multiple Myeloma / complications*
  • Multiple Myeloma / pathology
  • Neoplasm Staging
  • Osteocalcin / blood*
  • Peptides / blood*
  • Reference Values
  • Waldenstrom Macroglobulinemia / complications

Substances

  • Biomarkers
  • Collagen Type I
  • Peptides
  • collagen type I trimeric cross-linked peptide
  • Osteocalcin
  • Collagen