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Bioorg Med Chem Lett. 2006 Jan 1;16(1):31-5. Epub 2005 Nov 2.

Design, synthesis and in vitro antimalarial activity of an acylhydrazone library.

Author information

1
Institut de Biologie et Institut Pasteur de Lille, UMR CNRS 8525, Université de Lille II, 1 rue du Professeur Calmette, BP 447, 59021 Lille, France. patricia.melnyk@ibl.fr

Abstract

A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the iron chelator in widespread clinical use and also than the most effective chelators.

PMID:
16263280
DOI:
10.1016/j.bmcl.2005.09.058
[Indexed for MEDLINE]

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