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Bioorg Med Chem Lett. 2006 Feb;16(3):718-21. Epub 2005 Nov 2.

A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function.

Author information

1
Groton Laboratories, Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA. Robert.J.Chambers@pfizer.com

Abstract

Nicotinamide (2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function.

PMID:
16263279
DOI:
10.1016/j.bmcl.2005.10.026
[Indexed for MEDLINE]

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