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Mol Psychiatry. 2006 Feb;11(2):206-13.

Autism spectrum disorders associated with X chromosome markers in French-Canadian males.

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1
Centre Hospitalier de l'Université de Montréal, Research Centre, Notre Dame Hospital, Montreal, QC, Canada.

Abstract

It is now well established that genetic factors play an important role in the pathogenesis of autism disorder and converging lines of evidence suggest the implication of the X chromosome. Using a sample of subjects diagnosed with autism spectrum disorders, exclusively composed of males from French-Canadian (FC) origin, we tested markers covering the entire X chromosome using a family-based association study. Our initial analysis revealed the presence of association at two loci: DXS6789 (P=0.026) and DXS8043 (P=0.0101). In a second step, we added support to the association at DXS8043 using additional markers, additional subjects and a haplotype-based analysis (best obtained P-value=0.00001). These results provide support for the existence of a locus on the X chromosome that predisposes the FC to autism spectrum disorders.

PMID:
16261168
DOI:
10.1038/sj.mp.4001756
[Indexed for MEDLINE]
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