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Nat Neurosci. 2005 Dec;8(12):1660-2. Epub 2005 Oct 30.

Deficits in sexual and aggressive behaviors in Cnga2 mutant mice.

Author information

1
Neuroscience Graduate Program, Department of Anatomy, Box 2722, University of California San Francisco, San Francisco, California 94143, USA.

Abstract

Odors detected by the vomeronasal organ or the main olfactory epithelium (MOE) trigger social behaviors in many animals. It is unknown whether MOE neurons detect cues that initiate mating or aggression. We demonstrate that mice lacking functional CNGA2 (cyclic nucleotide-gated channel alpha2), which is required for odor-evoked MOE signaling, fail to mate or fight, suggesting a broad and essential role for the MOE in regulating these behaviors.

PMID:
16261133
DOI:
10.1038/nn1589
[Indexed for MEDLINE]

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