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Cancer Lett. 2006 Aug 28;240(2):183-94. Epub 2005 Nov 2.

KAI1/CD82, a tumor metastasis suppressor.

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Vascular Biology Center and Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.


Tetraspanin KAI1/CD82 is a wide-spectrum tumor metastasis suppressor. KAI1/CD82 suppresses tumor metastasis by primarily inhibiting cancer cell motility and invasiveness. In tetraspanin-enriched microdomain, KAI1/CD82 associates with the proteins important for cell migration such as cell adhesion molecule, growth factor receptor, and signaling molecule. Likely, KAI1/CD82 down-regulates the functions of these motility-related proteins to inhibit cell migration. The loss of KAI1/CD82 expression in invasive and metastatic cancers is due to a complex, epigenetic mechanism that probably involves transcription factors such as NFkappaB, p53, and beta-catenin.

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