Format

Send to

Choose Destination
Neurosci Lett. 1992 Feb 3;135(2):235-8.

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid.

Author information

1
Department of Pathology, New York University Medical Center, New York 10016.

Abstract

Many biochemically diverse proteins can give rise to amyloid fibrils; however, they are all accompanied by P component and glucosaminoglycans. With antibodies specific to apolipoprotein E (apo E) we used immunohistochemical techniques to test for the presence of this protein in both cerebral and systemic amyloid. We found apo E immunoreactivity in all tested types of cerebral and systemic amyloid. In amyloid deposits apo E P, component and glucosaminoglycans may be acting as 'pathological molecular chaperones'. The latter we define as a group of unrelated proteins that induce beta-pleated conformation in amyloidogenic polypeptides.

PMID:
1625800
DOI:
10.1016/0304-3940(92)90444-c
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center