Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2006 Feb;16(3):710-3. Epub 2005 Oct 27.

Generation of potent coagulation protease inhibitors utilizing zinc-mediated chelation.

Author information

1
Celera, 180 Kimball Way, South San Francisco, CA 94080, USA. Wendy.Young@Celera.com

Abstract

Inhibition of coagulation proteases such as thrombin, fXa, and fVIIa has been a focus of ongoing research to produce safe and effective antithrombotic agents. Herein, we describe a unique zinc-mediated chelation strategy to streamline the discovery of potent inhibitors of fIIa, fXa, and fVIIa. SAR studies that led to the development of selective inhibitors of fXa will also be detailed.

PMID:
16257204
DOI:
10.1016/j.bmcl.2005.10.023
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center