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Expert Opin Investig Drugs. 2005 Nov;14(11):1419-34.

Investigations on gossypol: past and present developments.

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Sunderland Pharmacy School, University of Sunderland, Sunderland SR1 3SD, UK.

Erratum in

  • Expert Opin Investig Drugs. 2006 Feb;15(2):193. Anderson, Rosaleen J [add]; Small, David A P [add]; Groundwater, Paul W [add].


Gossypol has received significant attention as a result of its potential therapeutic application as a male antifertility agent. Furthermore, recent research examining the biological activity of gossypol has revealed a number of other promising lines of enquiry. These have focused on the antitumour, antiviral and antioxidant actions of the compound in various disease states. This article provides an overview of the studies on the biological activity of gossypol, with particular attention paid to the mechanisms of its activity and its prospect as a medicinal product.

[Indexed for MEDLINE]

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