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Eur J Clin Nutr. 2005 Nov;59 Suppl 2:S8-12.

Screening and recruitment procedure of late-middle aged and older subjects: the ZENITH study.

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  • 1National Institute for Food and Nutrition Research, Human Nutrition Unit, Rome, Italy.



To report the rational, design, recruitment, baseline characteristics and preliminary overview of volunteers in the ZENITH study.


A multicentre prospective intervention study employing a randomised double-blind design.


Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy).


Healthy men and women middle-aged (55-70 y) and older volunteers (70-87 y).


At baseline (prior to zinc (Zn) supplementation), all volunteers underwent a full clinical examination, anthropometric measurements, health and lifestyle questionnaire, Mini Mental State Examination, Geriatric Depression Scale, and biochemistry profile.


In total, 842 volunteers (378 men and 464 women) were invited to take part in the study. A total of 49% of these volunteers were excluded on the basis of inclusion/exclusion criteria. In total, 433 participants were admitted to the Zn supplementation for 6 months. During this period, about 10% of volunteers dropped out from the study.


A total of 387 subjects (197 male and 190 female subjects) successfully completed the supplementation phase of the ZENITH study.

[PubMed - indexed for MEDLINE]
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