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J Cell Sci. 2005 Nov 1;118(Pt 21):4937-46.

CZH proteins: a new family of Rho-GEFs.

Author information

1
Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA. nm3h@virginia.edu

Abstract

The Rho family of small GTPases are important regulators of multiple cellular activities and, most notably, reorganization of the actin cytoskeleton. Dbl-homology (DH)-domain-containing proteins are the classical guanine nucleotide exchange factors (GEFs) responsible for activation of Rho GTPases. However, members of a newly discovered family can also act as Rho-GEFs. These CZH proteins include: CDM (Ced-5, Dock180 and Myoblast city) proteins, which activate Rac; and zizimin proteins, which activate Cdc42. The family contains 11 mammalian proteins and has members in many other eukaryotes. The GEF activity is carried out by a novel, DH-unrelated domain named the DOCKER, CZH2 or DHR2 domain. CZH proteins have been implicated in cell migration, phagocytosis of apoptotic cells, T-cell activation and neurite outgrowth, and probably arose relatively early in eukaryotic evolution.

PMID:
16254241
DOI:
10.1242/jcs.02671
[Indexed for MEDLINE]
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