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Best Pract Res Clin Gastroenterol. 2005 Oct;19(5):729-38.

Neuroendocrine tumours (carcinoids) of the appendix.

Author information

1
Elbe Klinikum Stade, Bremervörderstr. 111, 21684 Stade, Germany.

Abstract

Neuroendocrine tumours (NETs) of the appendix (formerly 'carcinoids') are rare and are usually detected incidentally after appendectomy. Histopathologically they derive from a subepithelial cell population, which is different from NETs in other sites. They are preferentially located at the tip of the appendix. Tumours <1 cm hardly ever metastasize and are treated by appendectomy. Tumours >2 cm require right hemicolectomy because of a significant risk of metastatic spread. Treatment for lesions 1-2 cm is controversial and needs further characterization of the tumour (i.e. mesoappendiceal invasion, vascular invasion, mitotic activity, proliferation markers) and careful patient risk evaluation. Goblet-cell carcinoids have features resembling both carcinoid and adenocarcinoma and should be treated by hemicolectomy. Overall prognosis of small appendiceal NET is excellent in all ages.

PMID:
16253897
DOI:
10.1016/j.bpg.2005.06.003
[Indexed for MEDLINE]

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