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Fitoterapia. 2005 Dec;76(7-8):722-4. Epub 2005 Oct 25.

Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice.

Author information

1
Pharmaceutical Research Center, Faculty of Pharmacy, Mashad University of Medical Sciences, Mashhad, Iran. hosseinzadehh@mums.ac.ir

Abstract

The anticonvulsant activities of Crocus sativus stigma constituents, safranal and crocin, were evaluated in mice using pentylenetetrazole (PTZ)-induced convulsions in mice. Safranal (0.15 and 0.35 ml/kg, i.p.) reduced the seizure duration, delayed the onset of tonic convulsions and protected mice from death. Crocin (200 mg/kg, i.p.) did not show anticonvulsant activity.

PMID:
16253437
DOI:
10.1016/j.fitote.2005.07.008
[Indexed for MEDLINE]

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