Format

Send to

Choose Destination
Trends Pharmacol Sci. 2005 Dec;26(12):654-60. Epub 2005 Oct 25.

An emerging role for PtdIns(4,5)P2-mediated signalling in human disease.

Author information

1
Department of Cellular Biochemistry, the Netherlands Cancer Institute, AvL ziekenhuis, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. j.halstead@nki.nl

Abstract

Although an established regulator of many cellular functions, the phosphoinositide phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2) appears to have evaded the attention of drug-discovery companies. An increasing number of reports have identified potential links between PtdIns(4,5)P2-mediated signalling pathways and the aetiology of many human diseases. Here, we review current knowledge of the regulation and function of PtdIns(4,5)P2 and discuss how aberrant PtdIns(4,5)P2-mediated signalling might contribute to human pathologies such as cardiac failure, bipolar disorder, channelopathies and the genetic disorder Lowe syndrome.

PMID:
16253350
DOI:
10.1016/j.tips.2005.10.004
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center