Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Neurosci. 2005 Nov;8(11):1442-4.

Plasticity of reward neurocircuitry and the 'dark side' of drug addiction.

Author information

1
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, 92037, USA. gkoob@scripps.edu

Abstract

Drug seeking is associated with activation of reward neural circuitry. Here we argue that drug addiction also involves a 'dark side'--a decrease in the function of normal reward-related neurocircuitry and persistent recruitment of anti-reward systems. Understanding the neuroplasticity of the dark side of this circuitry is the key to understanding vulnerability to addiction.

PMID:
16251985
DOI:
10.1038/nn1105-1442
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center