Format

Send to

Choose Destination
Nat Neurosci. 2005 Nov;8(11):1442-4.

Plasticity of reward neurocircuitry and the 'dark side' of drug addiction.

Author information

1
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, 92037, USA. gkoob@scripps.edu

Abstract

Drug seeking is associated with activation of reward neural circuitry. Here we argue that drug addiction also involves a 'dark side'--a decrease in the function of normal reward-related neurocircuitry and persistent recruitment of anti-reward systems. Understanding the neuroplasticity of the dark side of this circuitry is the key to understanding vulnerability to addiction.

PMID:
16251985
DOI:
10.1038/nn1105-1442
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center