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Nature. 2005 Oct 27;437(7063):1279-85.

Insights from studying human sleep disorders.

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Minnesota Regional Sleep Disorders Center, and Department of Neurology, Hennepin County Medical Center, and University of MN Medical School, Minneapolis, Minnesota 55415, USA.


Problems with sleep are one of the commonest reasons for seeking medical attention. Knowledge gained from basic research into sleep in animals has led to marked advances in the understanding of human sleep, with important diagnostic and therapeutic implications. At the same time, research guided by human sleep disorders is leading to important basic sleep concepts. For example, sleep may not be a global, but rather a local, brain phenomenon. Furthermore, contrary to common assumptions, wakefulness, rapid eye movement (REM) and non-REM sleep are not mutually exclusive states. This striking realization explains a fascinating range of clinical phenomena.

[Indexed for MEDLINE]

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