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Eur J Hum Genet. 2006 Feb;14(2):253-5.

Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers.

Author information

1
Genetic Epidemiology & Bioinformatics Group, Human Genetics Division, University of Southampton, Southampton, UK.

Abstract

FMR1 premutations are known to be associated with premature ovarian failure (POF), but the underlying mechanism is unknown. We present evidence for a nonlinear association between menopause age and premutation size suggesting that premutations in the mid-size range are at greatest risk for POF, while larger premutations are at lower risk.

PMID:
16251893
PMCID:
PMC3725422
DOI:
10.1038/sj.ejhg.5201510
[Indexed for MEDLINE]
Free PMC Article

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