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J Neurol Sci. 1992 Mar;108(1):32-4.

The association of astrocytoma and pituitary adenoma in a patient with alcaptonuria.

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  • 1Department of Endocrinology, University of Antwerp, Belgium.


A female patient with a juvenile pilocytic astrocytoma and a pituitary adenoma is described. The patient also has alcaptonuria, a rare inborn error of metabolism with autosomal recessive mode of inheritance. The association of these three disorders has never been reported previously. The possible existence of a common genetic factor in the development of both tumors and alcaptonuria is discussed.

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