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Bioorg Med Chem Lett. 2006 Jan 15;16(2):267-70. Epub 2005 Oct 21.

Biphenyl-4-ylcarbamoyl thiophene carboxylic acids as potent DHODH inhibitors.

Author information

1
4SC AG, Am Klopferspitz 19a, 82152 Martinsried, Germany. leban@4sc.com

Abstract

A previously discovered DHODH inhibitor series was further improved by replacing the cyclopentene ring by aromatic heterocycles. Different isomers of these compounds were prepared by the directed ortho-metallation procedure. The compounds are more active than the corresponding cyclopentene analogs and show potent effects on PBMC's proliferation.

PMID:
16246558
DOI:
10.1016/j.bmcl.2005.10.011
[Indexed for MEDLINE]

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