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Brain Res. 2005 Nov 9;1061(2):124-7. Epub 2005 Oct 24.

Adenosine A1 receptors mediate inhibition of cAMP formation in vitro in the pontine, REM sleep induction zone.

Author information

1
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Gerald.Marks@UTSouthwestern.edu

Abstract

Microinjection of adenosine A1 receptor agonist or an inhibitor of adenylyl cyclase into the caudal, oral pontine reticular formation (PnOc) of the rat induces a long-lasting increase in REM sleep. Here, we report significant inhibition of forskolin-stimulated cAMP in dissected pontine tissue slices containing the PnOc incubated with the A1 receptor agonist, cyclohexaladenosine (10(-8) M). These data are consistent with adenosine A1 receptor agonist actions on REM sleep mediated through inhibition of cAMP.

PMID:
16246314
DOI:
10.1016/j.brainres.2005.08.038
[Indexed for MEDLINE]

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