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Biochem Soc Trans. 2005 Dec;33(Pt 6):1375-7.

Thiol redox control via thioredoxin and glutaredoxin systems.

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1
Department of Medical Biochemistry and Biophysics, The Medical Nobel Institute for Biochemistry, Karolinska Institutet, SE-17177 Stockholm, Sweden. Arne.Holmgren@mbb.ki.se

Abstract

The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms. Here, we give a brief overview of the human Trx and Grx systems. The main part focuses on our current knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis during oxidative stress-induced apoptosis.

PMID:
16246122
DOI:
10.1042/BST20051375
[Indexed for MEDLINE]
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