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Biochem Soc Trans. 2005 Dec;33(Pt 6):1308-12.

Genetic, biochemical and structural approaches to talin function.

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1
Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK. drc@le.ac.uk

Abstract

The cytoskeletal protein talin plays a key role in coupling the integrin family of cell adhesion molecules to the actin cytoskeleton. In this paper I present a brief review on talin and summarize our recent studies, in which we have taken both genetic and structural approaches to further elucidate the function of the protein.

PMID:
16246105
DOI:
10.1042/BST20051308
[Indexed for MEDLINE]
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