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J Clin Microbiol. 1992 Jun;30(6):1457-61.

Detection of borreliacidal antibodies in hamsters by using flow cytometry.

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1
Wisconsin State Laboratory of Hygiene, Department of Medical Microbiology and Immunology, University of Wisconsin, Madison 53706.

Abstract

Flow cytometry can be used to detect antibody that kills Borrelia burgdorferi. Borreliacidal activity was detected within 3 h of incubating B. burgdorferi with immune serum and complement. Right-angle light scatter and propidium iodide fluorescence were the cytometric parameters which correlated best with in vitro killing of B. burgdorferi. Flow cytometry is a rapid method for determining the presence of borreliacidal activity and may lead to a better serodiagnostic test for the detection of Lyme disease.

PMID:
1624563
PMCID:
PMC265310
[Indexed for MEDLINE]
Free PMC Article
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