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Prostate. 2006 Feb 15;66(3):294-304.

Targeting of pericytes diminishes neovascularization and lymphangiogenesis in prostate cancer.

Author information

1
La Jolla Institute for Molecular Medicine, San Diego, California 92121, USA. ozerdem@ljimm.org

Abstract

BACKGROUND:

The walls of capillaries in prostate cancer are composed of endothelial cells, and pericytes. NG2 is a transmembrane proteoglycan on nascent pericytes with a functional role in neovascularization.

METHODS:

The anti-angiogenic effect of hydron pellets containing NG2 neutralizing antibody was quantified in intracorneal PC-3 and LNCaP xenografts. TRAMP and TRAMP-C1 tumors grafted in NG2 knockout mice represented intrinsic pericyte targeting. TRAMP and TRAMP-C1 grafts were analyzed with confocal microscope for microvascular density (MVD) and lymphatic vascular density (LVD).

RESULTS:

NG2 neutralizing antibody decreased corneal neovascularization in PC3 (P<0.0001), and LNCaP (P=0.0079) xenografts. Mean MVD in TRAMP and TRAMP-C1 tumors in NG2 knockout mice were 71% (P=0.0006) and 63% (P=0.0011) lower than wild type controls, respectively. Mean LVD in TRAMP and TRAMP-C1 tumors in NG2 knockout mice were 73% (P=0.0003) and 84% (P<0.0001) lower than wild type controls, respectively.

CONCLUSIONS:

Targeting of pericyte-NG2 decreases neovascularization and lymphangiogenesis in prostate cancer significantly.

PMID:
16245280
DOI:
10.1002/pros.20346
[Indexed for MEDLINE]
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