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Nat Struct Mol Biol. 2005 Nov;12(11):1019-20.

Induced structure of a helical switch as a mechanism to regulate enzymatic activity.

Author information

1
Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, USA.

Abstract

Herpesviruses encode a protease that is activated by homodimerization at high enzyme concentrations during lytic replication. The homodimer contains two active sites, which are distal from the dimer interface. Assignment of backbone NMR resonances and engineering of a redox switch show that two helices position a loop containing catalytic residues within each active site.

PMID:
16244665
DOI:
10.1038/nsmb1006
[Indexed for MEDLINE]

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