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Nat Struct Mol Biol. 2005 Nov;12(11):1015-6.

ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the membrane.

Author information

1
Institut für Biochemie der Charité, University Medical School Berlin, Monbijoustr. 2, 10117 Berlin, Germany.

Abstract

Ribosomes translating secretory and membrane proteins are targeted to the endoplasmic reticulum membrane and attach to the protein-conducting channel and ribosome-associated membrane proteins (RAMPs). Recently, a new RAMP, ERj1p, has been identified that recruits BiP to ribosomes and regulates translational activity. Here we present the cryo-EM structure of a ribosome-ERj1p complex, revealing how ERj1p coordinates the ribosome at the membrane and how allosteric effects may mediate ERj1p's regulatory activity.

PMID:
16244660
DOI:
10.1038/nsmb998
[Indexed for MEDLINE]

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