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J Leukoc Biol. 2006 Jan;79(1):166-72. Epub 2005 Oct 21.

Ceramide catabolism critically controls survival of human dendritic cells.

Author information

1
Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

Abstract

The regulation of dendritic cell (DC) survival is crucial for the modulation of adaptive immunity. Ceramide is a lipid mediator of the stress response, which accumulates intracellularly during DC differentiation. We found that ceramide levels are tightly regulated in human DCs and that the pharmacological inhibition of enzymes responsible for ceramide catabolism, such as ceramidases and sphingosine kinases, sensitizes DCs to ceramide-induced cell death. It is important that inhibition of sphingosine kinases, during lipopolysaccharide stimulation, causes extensive ceramide accumulation and death of DCs. These data indicate that ceramide catabolism regulates survival of human DCs and reveal novel potential targets for the pharmacological manipulation of the immune response.

PMID:
16244104
DOI:
10.1189/jlb.1004601
[Indexed for MEDLINE]

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