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Drug Discov Today. 2005 Nov 1;10(21):1451-8.

PEGylation, successful approach to drug delivery.

Author information

1
Department of Pharmaceutical Sciences, Padua University, Italy. francesco.veronese@unipd.it

Abstract

PEGylation defines the modification of a protein, peptide or non-peptide molecule by the linking of one or more polyethylene glycol (PEG) chains. This polymer is non-toxic, non-immunogenic, non-antigenic, highly soluble in water and FDA approved. The PEG-drug conjugates have several advantages: a prolonged residence in body, a decreased degradation by metabolic enzymes and a reduction or elimination of protein immunogenicity. Thanks to these favorable properties, PEGylation now plays an important role in drug delivery, enhancing the potentials of peptides and proteins as therapeutic agents.

PMID:
16243265
DOI:
10.1016/S1359-6446(05)03575-0
[Indexed for MEDLINE]

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