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J Am Acad Dermatol. 2005 Nov;53(5):769-74.

Long-term treatment of photoaged human skin with topical retinoic acid improves epidermal cell atypia and thickens the collagen band in papillary dermis.

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1
Department of Dermatology, University of Michigan Medical School, USA.

Abstract

BACKGROUND:

Risk of photocarcinogenesis and the relevance of collagen in wrinkle effacement are two issues related to prolonged use of retinoic acid (RA) that have not been fully addressed.

OBJECTIVE:

Our purpose was to investigate the degree of epidermal cellular atypia and the thickness of papillary dermal collagen in photoaging after long-term use of RA.

METHODS:

Thirty-four subjects with photoaged skin were treated daily with 0.05% RA for at least 6 months. Epidermal cellular atypia was graded by means of a semiquantitative scale. Thickness of collagen band was measured by using image-analysis software.

RESULTS:

Compared with pretreatment findings, melanocytic and keratinocytic atypia was significantly reduced and the collagen band thickness doubled.

LIMITATIONS:

This was an open-label study.

CONCLUSION:

Improvement in epidermal cellular atypia is consistent with the ability of RA to act as a chemopreventive agent in epithelial carcinogenesis. Prolonged use also significantly increased collagen matrix deposition in dermal repair zones, which most likely contributes to wrinkle effacement by RA.

PMID:
16243124
DOI:
10.1016/j.jaad.2005.06.052
[Indexed for MEDLINE]
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