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Epilepsy Behav. 2005 Dec;7 Suppl 3:S18-24. Epub 2005 Oct 19.

Models of epilepsy in the developing and adult brain: implications for neuroprotection.

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1
Department of Neurology, University of Wisconsin, Madison, WI 53792, USA. stafstrom@neurology.wisc.edu

Abstract

Repeated seizures cause a sequence of molecular and cellular changes in both the developing and adult brain, which may lead to intractable epilepsy. This article reviews this sequence of neuronal alterations, with emphasis on the kindling model. At each step, the opportunity exists for strategic intervention to prevent or reduce the downstream consequences of epileptogenesis and seizure-induced adverse plasticity. The concept of seizure-induced brain damage must be expanded to include behavioral and cognitive deficits, as well as structural neuronal damage and increased predisposition to seizures.

PMID:
16242383
DOI:
10.1016/j.yebeh.2005.08.005
[Indexed for MEDLINE]
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