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Osteoarthritis Cartilage. 2006 Jan;14(1):13-29. Epub 2005 Oct 19.

Osteoarthritis cartilage histopathology: grading and staging.

Author information

1
Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada. kpritzker@mtsinai.on.ca

Abstract

OBJECTIVE:

Current osteoarthritis (OA) histopathology assessment methods have difficulties in their utility for early disease, as well as their reproducibility and validity. Our objective was to devise a more useful method to assess OA histopathology that would have wide application for clinical and experimental OA assessment and would become recognized as the standard method.

DESIGN:

An OARSI Working Group deliberated on principles, standards and features for an OA cartilage pathology assessment system. Using current knowledge of the pathophysiology of OA morphologic features, a proposed system was presented at OARSI 2000. Subsequently, this was widely circulated for comments amongst experts in OA pathology.

RESULTS:

An OA cartilage pathology assessment system based on six grades, which reflect depth of the lesion and four stages reflecting extent of OA over the joint surface was developed.

CONCLUSIONS:

The OARSI cartilage OA histopathology grading system appears consistent and simple to apply. Further studies are required to confirm the system's utility.

PMID:
16242352
DOI:
10.1016/j.joca.2005.07.014
[Indexed for MEDLINE]
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