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Nat Rev Cancer. 2005 Nov;5(11):876-85.

Promoting apoptosis as a strategy for cancer drug discovery.

Author information

1
Cancer Research, Abbott Laboratories, Department R460, Building AP10-LL, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA. stephen.fesik@abbott.com

Erratum in

  • Nat Rev Cancer. 2005 Dec;5(12):995.

Abstract

Apoptosis is deregulated in many cancers, making it difficult to kill tumours. Drugs that restore the normal apoptotic pathways have the potential for effectively treating cancers that depend on aberrations of the apoptotic pathway to stay alive. Apoptosis targets that are currently being explored for cancer drug discovery include the tumour-necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors, the BCL2 family of anti-apoptotic proteins, inhibitor of apoptosis (IAP) proteins and MDM2.

PMID:
16239906
DOI:
10.1038/nrc1736
[Indexed for MEDLINE]

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