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Ann Rheum Dis. 2005 Nov;64 Suppl 4:iv77-80.

How does B cell depletion therapy work, and how can it be improved?

Author information

1
Department of Immunology and National Primate Research Center, Box 357330, University of Washington, Seattle, WA 98195, USA. eclark@bart.rprc.washington.edu

Abstract

The past few years have seen a surge of interest in B cell depletion therapy for patients with rheumatoid arthritis. This paper outlines the possible mechanism(s) by which B cell depletion therapy works. It is likely there is more than one mechanism and the relative importance of each mechanism depends on the target cell. These include CD20-induced apoptosis, complement dependent cytotoxicity, antibody dependent cell-mediated cytotoxicity, and selective targeting and depletion of B cell subsets. The implications of these mechanisms in the further improvement of B cell depletion therapy in rheumatoid arthritis and other autoimmune diseases are discussed.

PMID:
16239394
PMCID:
PMC1766898
DOI:
10.1136/ard.2005.042507
[Indexed for MEDLINE]
Free PMC Article
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