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Microbiol Immunol. 2005;49(10):937-9.

Mutation in IRO1 tightly linked with URA3 gene reduces virulence of Candida albicans.

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Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba, Japan.


Gene deletion in the pathogenic fungus Candida albicans has relied heavily on a URA3 cassette and a recipient delta ura3 strain CAI4. The IRO1 gene adjacent to URA3 was inadvertently deleted during construction of CAI4. We report here that a mutation in IRO1 reduces virulence of C. albicans.

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