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Asian Pac J Cancer Prev. 2005 Jul-Sep;6(3):304-8.

Anticarcinogenic effects of an aqueous infusion of cloves on skin carcinogenesis.

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Dept. of Cancer Chemoprevention, Chittarajan National Cancer Institute, 37 S.P. Mukherjee Road, Kolkata 700026, West Bengal, India.


Spices and flavouring agents are now receiving increasing attention as many of them have been shown to have anticarcinogenic properties. Cloves, sun-dried unopened flower buds from the plant Syzygium aromaticum L, are commonly used as a spice and food flavour. The present study was designed to investigate the chemopreventive action of aqueous infusion of cloves on 9,10-dimethyl benz(a)anthracene (DMBA) and croton oil induced skin carcinogenesis in Swiss mice. The results indicate protection against skin papilloma formation in a dose dependent manner. It has been shown that oral administration of aqueous infusions of clove at a dose of 100 microl/mouse/day not only delays the formation of papilloma but also reduces the incidence of papilloma as well as the cumulative number of papillomas per papilloma bearing mouse. Our observations suggest a promising role for cloves in restriction of the carcinogenesis process.

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